Duloxetine (generic for Cymbalta®)

Not feeling your best? You’re not alone. Medication isn’t for everyone, but it can be life changing for those who need it. Consult with a psychiatry provider through our platform to help determine whether a medication like Duloxetine could be right for you and help you feel like yourself again.
FDA-approved for major depressive disorder
Prescribed by licensed psychiatry providers, if appropriate
Online evaluation and ongoing check-ins
Product Overview

What Is Duloxetine

Duloxetine is an antidepressant medication, specifically an SNRI (serotonin-norepinephrine reuptake inhibitor). Duloxetine was first FDA approved in 2004 and sold under the brand names Cymbalta and others. Duloxetine requires a prescription for use in the United States.

Duloxetine Uses

Duloxetine is FDA approved to treat generalized anxiety disorder (GAD) and major depressive disorder (MDD). It is also indicated for certain other conditions related to nerve pain, including diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Treatment for nerve pain is not available through our platform. Those seeking care for nerve pain should consider seeing a medical provider outside our platform to evaluate potential options for treatment.

How Duloxetine Works

Scientists believe duloxetine works by discouraging nerves in the brain (neurons) from absorbing two substances, serotonin and norepinephrine, thereby increasing their circulation in the brain. This can have effects on psychiatric disorders, such as anxiety and depression.
What to expect

Get Duloxetine Online

Consultation with a psychiatrist or other qualified psychiatry provider online through our platform. If prescribed Duloxetine, genuine duloxetine hcl will be shipped to you discreetly. You’ll have ongoing check-ins with a health care provider to evaluate whether your treatment plan is working.

Duloxetine Side Effects

The most common side effects of duloxetine include nausea, dry mouth, sleepiness, fatigue, constipation, loss of appetite, dizziness, and increased sweating. Duloxetine can affect blood pressure, which should be monitored. Discuss any side effects you experience with your provider.

Drug Interactions

Duloxetine can interact with a variety of substances, including some common medications as well as supplements. Substances that may interact include but are not limited to: other antidepressants, monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs (NSAIDs), St. John's Wort, L-tryptophan and more. Risk of serotonin syndrome (toxicity when there is too much serotonin in the system) increases when combined with any substance that increases serotonin.
Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate.

what to expect

a seamless experience with an online psychiatry provider.


Online psychiatric evaluation

Consult via video chat with an online psychiatry provider, who will evaluate you and assess whether medication is appropriate


Private, ongoing follow-ups and medication management

A few weeks after your first appointment, you’ll have your first follow-up to evaluate whether your treatment plan is working—all on your smartphone


Discreet shipping to your door

If prescribed, your medication will be shipped to your door in low-key packaging

we've got answers

Frequently asked questions about Duloxetine

how does Duloxetine (generic for Cymbalta) make you feel?
When taken as prescribed, Duloxetine has been shown to treat symptoms of anxiety and depression. Notably, studies show duloxetine has an analgesic effect on painful physical symptoms of MDD, and this effect is partially independent of improvement in MDD.
how long does it take for Duloxetine (generic for Cymbalta) to work?
Duloxetine was shown to be effective as a treatment for anxiety and depression in clinical trials lasting 8-10 weeks. Consult with your healthcare provider if you do not think your condition is getting better.
does Duloxetine (generic for Cymbalta) cause weight gain?
According to one study in JAMA Psychiatry, Duloxetine was associated with a slight increase in weight after initial prescription. However, this increase was approximately 1% of body weight over 12 months, which was less than other antidepressant medication options.
does Duloxetine (generic for Cymbalta) help with anxiety?
Duloxetine is FDA-approved to treat generalized anxiety disorder. However, Duloxetine is not for people who experience occasional anxiety caused by normal life events.

Important Safety Information

If you're in emotional distress, text HOME to connect with a counselor immediately
If you're having a medical or mental health emergency, call 911 or go to your local ER